The Parallel Fears Driving Perceptions of AI and Genomics

In a recent statement, Food and Drug Administration (FDA) Commissioner Scott Gottlieb announced that the Agency would be releasing a new framework addressing regenerative medicine sometime before the end of 2017. This is a heartening development, especially given the Commissioner’s focus on developing “clearer lines” regarding the Agency’s authorities and oversight mechanisms for new and innovative medical technologies. As Adam Thierer and Jordan Reimschisel of the Mercatus Center point out in a recent article, this innovation-friendly perspective will be especially important in helping to usher in an age of more personalized medicine made possible by advancements in gene therapy and genetic modification treatments. Unfortunately, the road ahead is likely fraught with fear.

People are often skeptical of the likelihood that emerging technologies will end up delivering on purported promises. However, that healthy skepticism very quickly turns to anxiety once notable milestones in its development are reached. At that point, the public discourse quickly and inevitably shifts away from “uncertainty” towards “rising panic”—the initial stage of the techno-panic cycle. Indeed, as I’ve discussed previously, we’re already at the peak hysteria phase of this cycle with regards to perceptions of artificial intelligence (AI), even with potentially momentous economic gains close at hand. While a similar hysteria hasn’t yet materialized with regards to genetic modification technology, it’s ascent is likely close at hand, and will only grow with each new research milestone. So how does the current AI techno-panic compare to what’s likely coming down the road for genetic modification?

To start, public attitudes towards AI and genetics are primarily defined by narrative themes in popular culture and media. Terminator has been a driving source of fears over AI, portending a war-torn post-apocalyptic hellscape in which human civilization gives way to the onslaught of killer robots. Likewise, the movie Gattaca echoes concerns over the possibilities that advanced genetic manipulation will lead to a society of perpetual class stratification based on the genetic haves and have nots, resulting in an everlasting eugenic dystopia. Both visions are representative of the worst types of apocalyptic doomsaying, and neither is grounded in a realistic assessment of what these technologies are actually capable of.

But the similarities don’t stop at blockbuster hits.

At a technical level, the core of AI systems are processes by which seemingly inscrutable algorithms make decisions. In the same way that AI is something of a “black box,” so too are the cells in the human body. There’s a great deal we still don’t understand about how (or why) certain processes within cells unfold the way they do. This is especially true when discussing the limitations of CRISPR technology. It’s unclear why some guide RNAs work better than others at targeting nucleotides along the DNA helix. Nor can we fully understand why certain types of cells prefer the use of one type of genetic repair pathway over another. (For a detailed look at these limitations, I highly recommend this TED talk by Dr. Ellen Jorgensen.)

In short, our limited knowledge of AI decision-making and molecular biology is a significant limiting factor on what we can achieve. Just as we cannot create conscious synthetic systems capable of human-level intelligence, nor can we design therapies or treatments that allow us full control over genetic expression. The complexities of molecular biology are at least the equivalent of those involved in AI systems. (Ironically, the recognition of these similarities in complexities has actually driven a great deal of applied AI research into “genetic algorithms”—programs designed to find near-optimal solutions to complex problems that are based on biological evolutionary design properties.)

Edward Dickson discussed many of these parallels almost three decades ago in an article for AI Magazine. Even back in 1984 he recognized that “[t]here are many striking similarities that suggest that examination of the commercialization of genetic engineering contains lessons valuable to the budding artificial intelligence industry.” Among other insights into the then-emerging fields of AI and genetics, he was keenly aware of the potential public backlash against the normalization of these two fields, noting that:

AI and genetic engineering are both names with which the general public cannot feel immediately comfortable. These futuristic names carry within them the hint of meddling in areas best left alone.

As the techno-panic surrounding AI reaches levels of peak hysteria, we should be prepared to encounter those same anxieties in the context of genetic modification. Policymakers and regulators would do well to take a balanced and measured approach in parsing outlandish fears from scientific realities. We cannot anticipate how, precisely, the age of genomics will materialize; the research milestones are not likely to suddenly and unpredictably open the doors to “designer babies” or induce an overnight Gattaca-style transformation of our society. To that end, as we inch ever closer towards the inevitable genetic modification scare, policymakers should embrace policies that promote, rather than inhibit, new scientific innovations. “The main lesson,” according to Dixon, “is that the future will be good, but its evolution will be different than [we] imagine.”

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from nicholemhearn digest https://niskanencenter.org/blog/parallel-fears-driving-perceptions-ai-genomics/

Ruxbin shutters abruptly after 7 years of foodie acclaim

The 32-seat BYOB West Town restaurant, which just finished a major renovation, will close in September for what chef/owner Edward Kim calls a sabbatical.

from nicholemhearn digest http://www.chicagobusiness.com/article/20170830/BLOGS09/170839989/ruxbin-shutters-abruptly-after-7-years-of-foodie-acclaim?utm_source=BLOGS09&utm_medium=rss&utm_campaign=chicagobusiness

The End of the Working Class

Big deals heat up west suburban apartment market

Deals for five properties totaling more than $350 million suggest the suburban Chicago apartment market is still going strong after a record year for multifamily sales.

from nicholemhearn digest http://www.chicagobusiness.com/realestate/20170830/CRED03/170839991/big-deals-heat-up-west-suburban-apartment-market?utm_source=CRED03&utm_medium=rss&utm_campaign=chicagobusiness

Lake Forest’s own roller coaster: this estate’s asking price

In the past seven years it’s gone in both directions. It went up this week by $3 million.

from nicholemhearn digest http://www.chicagobusiness.com/realestate/20170830/CRED0701/170839996/lake-forests-own-roller-coaster-this-estates-asking-price?utm_source=CRED0701&utm_medium=rss&utm_campaign=chicagobusiness

Mattis and the Military-Society Gap

A viral video of Secretary of Defense James Mattis giving an impromptu speech to U.S. military personnel began making the rounds this weekend. In it, Mattis tells those present that the country has problems that the military does not. He implores them to “hold the line,” before articulating the “two powers” the United States has. The first is the “power of inspiration,” which he believes the country is lacking at the moment. The second is the “power of intimidation,” which is expressed through U.S. military power.

While it is understandable that some would take heart from the video and what they see as the steadiness of Mattis’ leadership, Mattis’ comments can also be interpreted as an example of an increasing gap between the military and the society it serves.

Fred Kaplan, a longtime commentator on national security affairs, had an interesting take on the video in his column for Slate. Kaplan saw in Mattis’ comments about the United States losing its power of inspiration a rebuke of the commander-in-chief. He worried that, while is better to have “adults” such as Mattis in positions of authority to contain Trump’s impulsiveness and incompetence, the speech by the secretary of defense could undermine civilian control of the military.

Toward the end of his piece Kaplan quotes Isaiah Wilson, a retired U.S. Army colonel now at the New America Foundation that focused on what Mattis’ comments said about the relationship between the military and American society. The passage is worth quoting in full:

However, Wilson is troubled by this particular passage in Mattis’ pep talk. The secretary of defense seemed to be telling his troops “that they are different and separate from—and morally better than—the nation itself,” Wilson told me on Monday. “This is a thin, dangerous line.” In the end, Wilson said, “this arrogant sense of professional self as ‘better than the public we serve’ will prove our undoing.” It could also erode “the vital and necessary trust that we now place—and must have—in our military. Once this kind of trust-bond is lost, it is hard, if not impossible, to recover. You can’t ‘surge’ trust.”

This is an important issue given the amount of trust the American people place in the U.S. military as an institution, as opposed to that which they place in elected civilians. It is important to avoid alarmism about a burgeoning crisis in civil-military relations. But coupled with other recent incidents, some of the sentiments expressed in Mattis’ comments suggest that relations between the U.S. military and American society are not in peak health at the moment.

While these issues predate the Trump administration, the forty-fifth president certainly seems likely to exacerbate them given his tendency to politicize the military. His recent speech on Afghanistan, for example, started off by referring to the members of the military as a “special class of heroes,” before suggesting the rest of society needs to emulate the unity—and, oddly, the loyalty—that military personnel display. But Trump’s predecessor expressed similar sentiments. In his 2012 State of the Union address, President Obama began by discussing the previous year’s mission to kill Osama bin Laden before pivoting to declare the U.S. military a model for how society should operate:

These achievements are a testament to the courage, selflessness and teamwork of America’s Armed Forces. At a time when too many of our institutions have let us down, they exceed all expectations. They’re not consumed with personal ambition. They don’t obsess over their differences. They focus on the mission at hand. They work together.

Imagine what we could accomplish if we followed their example.

Obama concluded with a similar theme: civilian society should be unified and mission-focused like the U.S. military.

And pundits are not immune to it either. A year before Obama lauded the military as a model for civilian society, Nicholas Kristof of the New York Times claimed that the U.S. military lives by “an astonishingly liberal ethos.” To back up this argument, Kristof cited the desegregation that occurred in the U.S. military prior to its occurrence in the American South, the smaller gap in pay that exists between general officers and enlisted than corporate executives and most companies’ janitorial staff, and the fact that the military’s health care system covers all those who serve.

While the U.S. military has sometimes been at the leading edge of issues related to equality and has provided opportunities for social mobility for some, military organizations are the opposite of “liberal.” For one, it was the civilian commander-in-chief, President Harry Truman, who ordered the military to desegregate. But more importantly, and by necessity, military organizations are hierarchical and authoritarian. They are so structured to ensure compliance and discipline in the execution of their organizational specialization. That specialization, as Samuel Huntington referred to it, is the management of violence.

To ask society to emulate the military is to ask it to no longer be liberal, free, or open. But encouraging a sense of moral superiority among the military is dangerous as well. Not only does it intensify the unquestioning reverence for the military among the public, it might also engender a sense of elitism among the military as an institution—where members might come to not only see themselves as a separate caste but one superior to the society they serve.

As discussed here previously, part of the problem lies in the lack of any tangible connection between American society and the military that serves it. The weak ties between society and the military have led to a situation where the former reveres the latter but has little knowledge of it. Mattis’ comments, while well intentioned, might have the same effect from the opposite direction if they encourage military personnel to see themselves as separate from and superior to the society they serve.

Matthew Fay is the Director of Foreign and Defense Policy Studies at the Niskanen Center

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from nicholemhearn digest https://niskanencenter.org/blog/mattis-military-society-gap/

Summer is ending but the fun goes on

Chicago Jazz Festival, five 10-minute plays staged for you alone, beach volleyball championships, African Festival of the Arts, an animation fest, and more.

from nicholemhearn digest http://www.chicagobusiness.com/article/20170830/NEWS0701/170829862/summer-is-ending-but-the-fun-goes-on?utm_source=NEWS0701&utm_medium=rss&utm_campaign=chicagobusiness

It’s the unofficial end of summer but not of fun

Chicago Jazz Festival, five 10-minute plays staged for you alone, beach volleyball championships, African Festival of the Arts, an animation fest, and more.

from nicholemhearn digest http://www.chicagobusiness.com/article/20170830/NEWS0701/170829862/its-the-unofficial-end-of-summer-but-not-of-fun?utm_source=NEWS0701&utm_medium=rss&utm_campaign=chicagobusiness

Why Amazon’s Whole Foods acquisition will not revolutionize food retailing anytime soon

Amazon has the money and ambition to upend the grocery industry. But Whole Foods alone won’t take the fearsome e-commerce company to the top of the food chain.

from nicholemhearn digest http://www.chicagobusiness.com/article/20170830/BLOGS10/170839997/why-amazons-whole-foods-acquisition-will-not-revolutionize-food?utm_source=BLOGS10&utm_medium=rss&utm_campaign=chicagobusiness